Scientists discuss in 'Non-steady-state calcium handling in failing hearts from the spontaneously hypertensive rat' new findings in cardiovascular research. "It is generally agreed that changes in Ca(2+) cycling are often associated with heart failure, yet the impact of these changes on a beat-to-beat basis remains unclear. Measurements of isometric force and [Ca(2+)](i) were made at 37[degrees]C in left ventricular trabeculae from failing spontaneously hypertensive rat (SHR) hearts, and their normotensive Wistar-Kyoto (WKY) controls," scientists in New Zealand report (see also Cardiovascular Research).
"At 1 Hz, peak stress was reduced in SHR (14.5?[+ or -]?2.4 mN mm(-2) …
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